KIDNEY / NEPHROLOGY NEWS

Cell therapy could replace need for kidney transplants

Scientists are working on a promising approach for treatment of chronic kidney disease -- regeneration of damaged tissues using therapeutic cells.

Central American kidney disease epidemic linked to occupational heat exposure

For two decades, Nicaragua and El Salvador have seen increasing mortality from an unusual form of chronic kidney disease (CKD), also called Mesoamerican Nephropathy (MeN). The disease has disproportionately affected sugarcane and other agricultural workers, and appears to be unrelated to traditional kidney disease risk factors such as diabetes.

Common blood pressure drug may increase cardiac arrest risk

A recent preliminary study concluded that a common drug that doctors prescribe to treat hypertension and angina may increase the risk of cardiac arrest.

POOR KIDNEY FUNCTION LINKED TO HIGHER CANCER RISK

In a study of adults in Sweden, poor kidney function was linked with a higher risk of certain cancers, especially skin and urogenital cancers.

STUDY PROVIDES NEW INSIGHTS ON COMMON POST-TRANSPLANT CONDITION

After examining comprehensive pathology findings and clinical, immunological, and outcome data pertaining to patients with transplant glomerulopathy, investigators identified 5 groups of patients with distinct features, as well as different outcomes in terms of survival rates of transplanted kidneys.

Simple urine test allows for rapid diagnosis of preeclampsia

About one in 20 women develop preeclampsia during pregnancy, which can be life-threatening to both moms and babies. However, it is difficult to diagnose because symptoms often mimic those of a normal pregnancy, such as swelling and headaches. Now a new innovation may help start treatment sooner by quickly identifying preeclampsia with a simple urine test. In a new study, researchers developed a fast and easy test to accurately diagnose the condition in just three minutes.

New Generic Blood Pressure Drug Is Approved to Relieve Shortages

The F.D.A. made the product review a priority, citing shortages that occurred in the wake of several recalls of drugs that were found to contain potentially cancer-causing chemicals.

Phys Ed: Exercise vs. Drugs to Treat High Blood Pressure and Reduce Fat

Exercise can lower blood pressure and reduce visceral body fat at least as effectively as many common prescription drugs, two new reviews report.

What to know about brown urine

Urine may be brown due to dehydration, liver disease, or certain foods and medications. Treatment depends on the underlying cause. Learn more about brown urine here.

Is high blood pressure always bad?

Most experts believe that doctors should treat hypertension as a risk factor. However, new research suggests that high blood pressure is not always bad.

TMVR Benefits Hold Firm in Post-Market Registry (CME/CE)

(MedPage Today) -- Do data point to a future 'transcatheter toolbox' for mitral disease?

Multivessel PCI Not Best in Cardiogenic Shock

(MedPage Today) -- Trial data show mortality disadvantage versus treating culprit lesions only

ASN 2017: The Future of Personalized Nephrology

(MedPage Today) -- Tissue engineering, drug discovery challenges among highlight topics

10 Questions to Challenge Your Medical News Savvy

(MedPage Today) -- Weekly News Quiz: October 20-26

Surgical Weight Loss; Low hs-cTNT Still Risky; VAD Before Pediatric Transplant

(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week

EndoBreak: T1D and Vitamin D; VA's T2D Guideline; Oral Acromegaly Drug

(MedPage Today) -- News and commentary from the endocrinology world

For SAVR, Afternoon Tops Morning for Surgical Safety (CME/CE)

(MedPage Today) -- Circadian genes appear to interact with ischemia-reperfusion injury effects

Robotic-Assisted Surgery Adds Time, Costs Without Affecting Outcomes (CME/CE)

(MedPage Today) -- No improvements compared with laparoscopic procedures in kidney removal and rectal cancer

RAS Blockade After TAVI Tied to Better Outcomes (CME/CE)

(MedPage Today) -- Patients with severe aortic stenosis see reduced all-cause mortality

Borderline Pulmonary Hypertension Tied to Mortality Risk

(MedPage Today) -- Small increases in pressure might signal left heart failure, not early PAH

What to know about lower right back pain

The possible causes of pain in the lower right area of the back include sprains, strains, infections, and spinal stenosis. Treatment depends on the underlying cause. Learn more here.

What to know about brown urine

Urine may be brown due to dehydration, liver disease, or certain foods and medications. Treatment depends on the underlying cause. Learn more about brown urine here.

What to know about acute renal failure

Signs of the kidneys failing include confusion, less urine output, and shortness of breath. Risk factors include age, diabetes, and high blood pressure. Learn more here.

What causes urethra pain in men and women?

Urethra pain can occur as a symptom of many different conditions ranging from urinary tract infections to kidney stones. Learn about the potential causes of urethra pain and their treatments here.

What causes flank pain?

Flank pain is pain that occurs on either or both sides of the torso, just below the ribs. The most common reason for flank pain is a muscle strain, but there are other possible underlying causes. Learn more here.

What to know about 24-hour cortisol urine tests

Doctors use cortisol urine tests to help diagnose many medical conditions that affect cortisol levels. In this article, we discuss the uses, procedure, and how to interpret the results of a 24-hour cortisol urine test.

What causes dark urine?

A variety of issues can cause dark urine, including foods, medication, and dehydration. Learn more about the potential causes and their treatments in this article.

What causes cloudy urine?

Cloudy urine can result from many different issues, including dehydration, urinary tract infections, and kidney stones. Learn more about the causes and treatments here.

New tool predicts kidney stone recurrence

Despite the prevalence of kidney stones, it is still difficult to predict who will experience recurrence. A new tool promises to make prediction easier.

Bladder cancer: What to know about BCG treatment

Bacillus Calmette–Guerin (BCG) treatment can help prevent cancer from returning following surgery for early-stage bladder cancer. Doctors deliver BCG directly to a person’s bladder using a catheter. Learn more about what BCG is, and what to expect during the procedure, here.

HYPERTENSION NEWS

Common blood pressure drug may increase cardiac arrest risk

A recent preliminary study concluded that a common drug that doctors prescribe to treat hypertension and angina may increase the risk of cardiac arrest.

Is high blood pressure always bad?

Most experts believe that people should treat hypertension as a risk factor. However, new research suggests that high blood pressure is not always bad.

Napping may be as good as drugs for lowering blood pressure

Researchers have now uncovered evidence that indulging in a midday nap can help control blood pressure levels about as well as taking medication.

Are black walnuts good for you?

Black walnuts have potential health benefits, including lowering cholesterol and blood pressure levels. Learn more about the benefits and side effects of black walnuts here.

Can mouthwash raise your blood pressure?

New research suggests that a substance commonly found in mouthwash destroys oral bacteria that help maintain normal blood pressure.

Blueberries may lower cardiovascular risk by up to 20 percent

New research finds that eating 200 grams of blueberries every day can reduce blood pressure and improve cardiovascular health among healthy individuals.

Todo lo que necesita saber sobre la hipertensión

La hipertensión puede derivar en una cardiopatía, un ACV y muerte, lo que la convierte en la mayor preocupación a nivel global. Muchos factores de riesgo pueden aumentar las oportunidades de que alguien la desarrolle, pero ¿puede evitarse?. Descubra las causas, síntomas, tipos y cómo prevenirla.

Hypertension: Home-based care may be the future

Controlling high blood pressure can be challenging. A recent study tests a more cost-effective, home-based approach, and the results are promising.

Is fenugreek good for you?

Fenugreek is an herb with many potential health benefits, including improving cholesterol and blood pressure. It may also cause some unwanted effects. Learn more about fenugreek here.

High blood pressure linked to zinc deficiency

A new study finds that zinc deficiency can play a role in high blood pressure. The researchers examine how zinc's impact on the kidney might be to blame.

GENERAL MEDICAL NEWS

Universal flu vaccine on the near horizon

SBS.com: Scientists at the Doherty Institute and Monash University say they have discovered immune cells that could fight off all forms of the flu virus, which could see an end to annual flu jabs. Depending on a patient's immune system, a cover-all flu shot would only be needed every 10 years, or potentially just once in a lifetime - and could help prevent thousands of deaths worldwide every year.

Alzheimer disease linked to brain infection by gingivitis bacteria.

New Scientist: Multiple research teams have been investigating P. gingivalis, and have so far found that it invades and inflames brain regions affected by Alzheimer’s; that gum infections can worsen symptoms in mice genetically engineered to have Alzheimer’s; and that it can cause Alzheimer’s-like brain inflammation, neural damage, and amyloid plaques in healthy mice.

Bone mass increased by 800% in a mouse model

Medical News Today: A groundbreaking set of studies has found that blocking certain receptors in the brain leads to the growth of remarkably strong bones. Could a new osteoporosis treatment be on the horizon?

Harvard Intensive Review of Nephrology 2018 now available

Intensive Review of Nephrology................ Harvard Medical School and Brigham and Women's Hospital Board Review Prep for ABIM Nephrology exams, expand your knowledge and integrate the latest guidelines into your daily practice................. Video Online - $1,395.00.......... Online + USB* - $1,495.00 ...............Audio MP3s: CDs - $1,495.00 ............USB* - $1,495.00...............Combo: Online Video + Audio MP3 CDs + USB - $2,095.00.

Randomized PIVOT trial published in NEJM suggests more IV iron is better.

NEJM (Macdougall): Conclusions: Among patients undergoing hemodialysis, a high-dose intravenous iron regimen administered proactively was noninferior to a low-dose regimen administered reactively and resulted in lower doses of erythropoiesis-stimulating agent being administered.

Increased mortality with citrate-containing dialysate - HDF fluid in France.

LeMonde: (in French -- paste this link into Google translate) ...les patients traités par un liquide de dialyse (ou dialysat) au citrate présenteraient une surmortalité de 40 % par rapport à ceux traités avec d’autres produits plus anciens à l’acétate ou à l’acide chlorhydrique (HCl).........Tel est le principal constat d’une étude rétrospective pilotée par Lucile Mercadal (Inserm, CESP 1018 et hôpital Pitié-Salpêtrière) réalisée avec une équipe de néphrologues et de biostatisticiens français (REIN-Agence de la biomédecine, ABM), à partir des données du registre national REIN. Elle a été présentée le ­3 octobre lors du congrès de la Société francophone de néphrologie, dialyse et transplantation ; elle n’est pas encore publiée.

Test detects presence of cancer in blood samples based on DNA methylation.

Medical Device Network: Researchers at University of Queensland in Australia have created a new diagnostic test that can identify the presence of a tumour in the body based on a unique, DNA nanostructure that appears to be common to all types of cancer.

Akkermansia gut bacteria and their role in insulin resistance and aging.

Orlando Sentinel: First, they documented that the guts of older animals had markedly smaller populations of A. muciniphila than the guts of young animals, and that as A. muciniphila became more scarce, so did butyrate, one of the gut’s key protectors. The deficiency of these two substances caused the mucous walls of the of the aged animals’ intestines to thin and grow leaky. That corrosive process unleashed a chain of events that touched off inflammation, prompted an immune response and, in a final step, increased insulin resistance.

KidneyX prize competition now open: Application deadline Feb 28, 2019

Phase 1 submission period open now..................... Phase 1 submission period ends: February 28, 2019, 5:00 p.m. ET.............. Phase 1 Awardees announced by: April 30, 2019............................. Phase 2 begins: April 15, 2019................................... In Phase 1, we are looking for designs of solutions that will address at least one of the following areas:......................... Replicating Kidney Functions (Blood Filtration, Electrolyte Homeostasis, Fluid Regulation, Toxin Removal and Secretion, and/or Filtrate Drainage and Connectivity).................................. Improving Patient Quality of Life (e.g., minimizing burden on the family and care partner(s), reducing disease and treatment complications, increasing mobility and physical activity)...................................... Improved renal replacement therapy access (vascular or peritoneal access) Addressing engineering challenges (e.g., preventing clotting, bleeding, and infection in vascular circuit and associated devices)............................ Ancillary technologies................... Biomaterials development.................... Biological and Immunological modulation..................... Biosensor development and other safety monitoring functions................

AKI and CRRT 2019 Conference, Feb 26 -- March 1, 2019, San Diego, CA

The learning objectives for this conference are as follows: 1. Describe the recent advances in the pathophysiology and management of critically ill patients with a focus on sepsis, multi-organ failure, infections, lung and kidney injury in different settings..................................... 2. Discuss the best ways to identify, treat and follow up patients with acute kidney injury (AKI) resulting from different causes utilizing biomarkers, imaging and lab studies and applying educational tools to raise awareness of AKI......................... 3. Describe the principles and practice of renal replacement techniques including CRRT, IHD and plasma exchange and demonstrate how to setup and use these techniques for managing critically ill patients.

Most teens report using marijuana less often after legalization

(Washington State University) Only one group of teenagers used marijuana more often after retail sales were legalized in Washington than they did before -- high school seniors who work 11 or more hours per week, according to new research led by a WSU College of Nursing professor.

The robots that dementia caregivers want: robots for joy, robots for sorrow

(University of California - San Diego) A team of scientists spent six months co-designing robots with informal caregivers for people with dementia, such as family members. They found that caregivers wanted the robots to fulfill two major roles: support positive moments shared by caregivers and their loved ones; and lessen caregivers' emotional stress by taking on difficult tasks, such as answering repeated questions and restricting unhealthy food.

Icosapent ethyl drug reduces risk of recurrent cardiovascular events

(Brigham and Women's Hospital) Further insights from the REDUCE-IT trial show that high-dose, pure and stable EPA omega 3 drug not only reduces the burden of first cardiovascular events but also subsequent and total heart attacks, strokes, and other measures.

Holocaust survivors with PTSD transmit negative views on aging to their adult offspring

(Bar-Ilan University) A new study provides first evidence that negative views on aging are transmitted in families of Holocaust survivors suffering from PTSD. They view themselves as aging less successfully compared to survivors without PTSD and older adults who weren't exposed to the Holocaust. Furthermore, offspring of posttraumatic Holocaust survivors negatively perceive the aging of their parents and consequently see themselves as aging less favorably, according to Prof. Amit Shrira, of Bar-Ilan University in Israel.

New global standard counts the cost of environmental damage

(Chalmers University of Technology) Environmental damage costs society enormous amounts of money -- and often leaves future generations to foot the bill. Now, a new ISO standard will help companies valuate and manage the impact of their environmental damage, by providing a clear figure for the cost of their goods and services to the environment.

Experimental blood test accurately spots fibromyalgia

(Ohio State University) For the first time, researchers have evidence that fibromyalgia can be reliably detected in blood samples -- work they hope will pave the way for a simple, fast diagnosis.

Higher consumption of sugary beverages linked with increased risk of mortality

(Harvard T.H. Chan School of Public Health) The more sugar-sweetened beverages (SSBs) people consumed, the greater their risk of premature death--particularly death from cardiovascular disease, and to a lesser extent from cancer, according to a large long-term study of US men and women. The risk of early death linked with drinking SSBs was more pronounced among women.

Sugary drinks may be associated with an increased risk of death from cardiovascular diseases

(American Heart Association) There was an association among people who drank the most sugary drinks and an increased risk of cardiovascular disease and other causes of death. Substituting one sugary drink a day with an artificially sweetened drink was associated with a slightly lower risk of dying, but drinking four or more artificially sweetened drinks a day was associated with a higher risk of death among women.

Fast-acting agent shows promise in reversing effects of ticagrelor

(Brigham and Women's Hospital) PB2452 provides immediate and sustained reversal of ticagrelor's antiplatelet effects

New cardiac pump clinically superior, safer for patients

(Brigham and Women's Hospital) The study of more than 1,000 patients with severe heart failure not only confirms that the HeartMate 3™, a next-generation LVAD device, markedly reduced the need for re-operations due to pump malfunctions, but also found that it lowered risk of bleeding events and strokes, compared to the HeartMate II™.