KIDNEY / NEPHROLOGY NEWS

Phosphorus Content Higher in Packaged Meats Listing Phosphate Additives

Additives in packaged meat, poultry, and fish can contribute significantly to the dietary phosphorus and potassium loads in CKD patients, researchers say.

Cytoreductive Nephrectomy Benefits for Metastatic RCC Demonstrated

Patients who underwent cytoreductive nephrectomy for metastatic non-clear cell renal cell carcinoma had a significantly decreased risk of cancer-related mortality.

CLINICAL TRIAL DOES NOT SUPPORT THE USE OF BORTEZOMIB FOR KIDNEY TRANSPLANT RECIPIENTS

• In a trial of kidney transplant recipients with late antibody-mediated rejection, treatment with bortezomib, a type of proteasome inhibitor, failed to improve the function of transplanted kidneys and prevent immunologic tissue injury. • Bortezomib treatment was also linked with gastrointestinal and hematologic toxicity.

SURVIVAL RATES ARE IMPROVING FOR INDIVIDUALS WITH KIDNEY FAILURE

• In the United States, the excess risk of kidney failure–related death decreased by 12% to 27% over any 5-year interval between 1995 and 2013. • Decreases in excess mortality over time were observed for all ages and both during treatment with dialysis and during time with a functioning kidney transplant.

Sucroferric Oxyhydroxide Efficacy Similar to That of Sevelamer

Serum phosphorus fell to similar levels in two-thirds of peritoneal dialysis patients, but sucroferric oxyhdroxide recipients had a lower pill burden.

ASN PARTNERS WITH VA CENTER FOR INNOVATION ON MY KIDNEY NUTRITION APP FEATURES CHALLENGE

Around 17% of American adults have chronic kidney disease (CKD), and the rate of prevalence is higher for US Veterans. CKD, if not treated appropriately, can ultimately lead to kidney failure requiring either dialysis or a transplant.

Preop Aerobic Exercise May Improve Cystectomy Outcomes

A feasibility study involving 60 patients with bladder cancer sought to determine if preoperative vigorous cardiovascular activity would improve postsurgical outcomes.

SHPT May Predict Left Ventricular Diastolic Dysfunction

iPTH significantly correlated with measures of diastolic dysfunction in patients with non-dialysis chronic kidney disease.

New compound stops progressive kidney disease in its tracks

Researchers describe a new approach to prevent death in essential kidney cells during kidney disease. Studying multiple animal models of kidney disease, the team discovered a compound that can impede loss of the filtration cells and restore kidney function. The work, inspired by an investigation into a genetic form of the condition, has the potential to affect therapeutic research for millions of people suffering from progressive kidney diseases.

CRISPR-Cas9 technique targeting epigenetics reverses disease in mice

Scientists report a modified CRISPR-Cas9 technique that alters the activity, rather than the underlying sequence, of disease-associated genes. The researchers demonstrate that this technique can be used in mice to treat several different diseases.

TMVR Benefits Hold Firm in Post-Market Registry (CME/CE)

(MedPage Today) -- Do data point to a future 'transcatheter toolbox' for mitral disease?

Multivessel PCI Not Best in Cardiogenic Shock

(MedPage Today) -- Trial data show mortality disadvantage versus treating culprit lesions only

ASN 2017: The Future of Personalized Nephrology

(MedPage Today) -- Tissue engineering, drug discovery challenges among highlight topics

10 Questions to Challenge Your Medical News Savvy

(MedPage Today) -- Weekly News Quiz: October 20-26

Surgical Weight Loss; Low hs-cTNT Still Risky; VAD Before Pediatric Transplant

(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week

EndoBreak: T1D and Vitamin D; VA's T2D Guideline; Oral Acromegaly Drug

(MedPage Today) -- News and commentary from the endocrinology world

For SAVR, Afternoon Tops Morning for Surgical Safety (CME/CE)

(MedPage Today) -- Circadian genes appear to interact with ischemia-reperfusion injury effects

Robotic-Assisted Surgery Adds Time, Costs Without Affecting Outcomes (CME/CE)

(MedPage Today) -- No improvements compared with laparoscopic procedures in kidney removal and rectal cancer

RAS Blockade After TAVI Tied to Better Outcomes (CME/CE)

(MedPage Today) -- Patients with severe aortic stenosis see reduced all-cause mortality

Borderline Pulmonary Hypertension Tied to Mortality Risk

(MedPage Today) -- Small increases in pressure might signal left heart failure, not early PAH

Remedies for ulcerative colitis constipation

Some people with ulcerative colitis experience frequent constipation. Learn about the treatment options, including magnesium and castor oil.

Acute kidney injury linked with heart failure

Acute kidney injury is a growing problem in the United States. According to the latest study, it may also increase the risk of heart failure.

What foods to eat if you have diarrhea

A limited diet can help a person reduce the symptoms of diarrhea. In this article, learn what foods to eat, what foods to avoid, and when to see a doctor.

How to lower creatinine levels

The best way to lower creatinine is to treat the underlying cause. There are also many diet and lifestyle changes that can help lower creatinine.

What causes pain in the lower left abdomen?

There are a range of conditions that can cause pain in the lower left abdomin, including gas, diverticulitis, and hernias. Learn more in this article.

What you need to know about gallbladder sludge

A look at gallbladder sludge, where various substances collect in the gallbladder. Included is information on its clinical significance and causes.

What is chronic diarrhea and how is it treated?

Learn all about chronic diarrhea, with a focus on why it might occur and what treatments and home remedies exist to relieve symptoms.

What causes diarrhea after eating?

Learn about postprandial diarrhea, or diarrhea after eating. This article examines the causes and treatment options for both acute and chronic PD.

Warm, wet weather: The key to kidney stones?

Earlier studies found a link between temperature and kidney stones. A new project finds that heat is not the only factor; humidity plays a part, too.

Are there any alternatives to Flomax?

BPH is a condition often treated with a drug called Flomax. A number of alternatives can help people with BPH relieve their symptoms and feel better.

HYPERTENSION NEWS

What is an intracerebral hemorrhage?

Intracerebral hemorrhage happens when blood suddenly leaks in the brain. It is a potentially life-threatening emergency. Learn more about the risk factors.

Common blood pressure drug raises skin cancer risk

New research shows that people who take the popular hypertension drug hydrochlorothiazide may put themselves at a dramatically high risk of skin cancer.

High blood pressure: Could diet replace medication?

Researchers suggest that the DASH diet, when combined with low salt intake, may be just as effective as medication for lowering high blood pressure.

The 10 best blood pressure apps

Blood pressure can be managed through apps that can track and monitor your levels and reduce your risk factors for developing high blood pressure.

Salt raises blood pressure, but our gut bacteria can stop it

New research shows that replenishing the friendly bacteria in our gut that are affected by too much salt may lower high blood pressure.

Do you have high blood pressure? You might, based on new guidelines

Almost half of adults in the United States are now classified as hypertensive, following a change to the guidelines for high blood pressure.

Skin may regulate blood pressure, study finds

The skin may respond to low-oxygen environments in a way that increases blood pressure and heart rate, according to a study in mice.

Women's dementia risk increased by midlife hypertension

Women who develop high blood pressure in their 40s may be at greater risk of dementia, a new study finds, but this association may not ring true for men.

Regular sauna use could slash men's hypertension risk

The risk of high blood pressure may be up to 46 percent lower for men who use a sauna at least twice weekly, a Finnish study suggests.

Nephroptosis: Causes, diagnosis, and treatment

A floating or mobile kidney is medically known as nephroptosis. In this article, we learn about causes, risk factors, and complications for this condition.

GENERAL MEDICAL NEWS

Toxic algae now a nationwide threat.

AP: MONROE, Mich. (AP) — Competing in a bass fishing tournament two years ago, Todd Steele cast his rod from his 21-foot motorboat — unaware that he was being poisoned. A thick, green scum coated western Lake Erie. And Steele, a semipro angler, was sickened by it.

HDCN server move still in progress

We are still in the process of moving our sever. The CME and CEU certificates don't yet work, so please hold off in taking any tests on the site. The old audio files from ASN and other meetings should work now. Suggest you use VLC player to access them -- even the old Windows Media player files as well as the Real Media files open well using this player. Get the VLC player at https://www.videolan.org/vlc/.

HDCN moving its registration and CME server

We are in the process of moving our registration and CME server, www.hdcn.net and all emails related to this server. There may be problems for the next few days until this server move is finished.

Hypervirulent, carbipenem-resistant Klebsiella pneumonia outbreak in China.

Ibankcoin: Scientists in Hangzhou, China have discovered a new strain of antibiotic-resistant pneumonia which spreads incredibly fast, after a 2016 outbreak in a hospital ICU led to the deaths of five patients ranging in age from 53 to 73. In findings published in The Lancet, researchers conclude that the new superbug poses a “substantial threat to human health” due to the fact that it is “simultaneously hypervirulent, multidrug resistant, and highly transmissible.”

ISHD Hemodialysis University, Chicago, IL Sept. 7-9, 2017; with CVC insertion precourse

ISHD: Come to the ISHD 2-day Hemodialysis University, to be held in Chicago at the Oak Lawn Hilton (4 miles south of Midway Airport), Sept. 7-9th. On Thursday, September 7th, registration permitting, we will hold a precourse focusing on CVC catheter insertion. For program and registration form click on the hyperlink, or go to http://www.ishd.org.

NEJM: Idarucizumab effective for reversal of dabigatran effects.

NEJM: Conclusions. In emergency situations, idarucizumab rapidly, durably, and safely reversed the anticoagulant effect of dabigatran.

Immunotherapy may arrest damage of beta cells in type 1 diabetes.

LA Times: After a quarter-century of failed efforts to treat diabetes with an immune therapy, the experimental treatment appeared to quell the immune system’s assaults on the body’s insulin-production machinery. The authors of the new study call their experimental treatment “an appealing strategy for prevention,” both in the earliest stages of Type-1 diabetes and in children who are at high genetic risk of developing the disease.

Fresenius inks deal to acquire NxStage.

Medical Device Online: Fresenius Medical Care intends to acquire all outstanding shares of NxStage through a merger for USD 30.00 per common share, thus the transaction would be valued at approximately USD 2.0 billion. The merger, which has been approved by NxStage’s board, is subject to approval of NxStage stockholders, receipt of regulatory approvals and other customary closing conditions. Fresenius Medical Care currently expects the closing to occur in 2018.

Gene-editing of pigs increases suitability of their organs for transplant into humans.

Telegraph (Sarah Knapton): Pig organs could soon be transplanted into patients after Harvard University genetically removed a virus inherent in the animal’s DNA which makes it incompatible with humans.

Can LIF be used to cure autoimmune diseases such as multiple sclerosis? and more?

Cambridge News: Dr. Su Metcalfe of LIFNano: "We’re not using any drugs, we’re simply switching on the body’s own systems of self-tolerance and repair. There aren’t any side effects because all we’re doing is tipping the balance. Auto-immunity happens when that balance has gone awry slightly, and we simply reset that. Once you’ve done that, it becomes self-sustaining and you don’t have to keep giving therapy, because the body has its balance back."

Study prompts new ideas on cancers' origins

(Washington University School of Medicine) Cancer therapies often target cells that grow and divide rapidly, such as stem cells, but in studying how stomach cancers occur, researchers at Washington University School of Medicine in St. Louis found that even when the stomach isn't able to make stem cells, other cells in the stomach can begin to divide and contribute to precancerous lesions.

Journal of Biomedical Optics and Neurophotonics to become fully open-access journals

(SPIE--International Society for Optics and Photonics) Two journals published by SPIE, the international society for optics and photonics, will become fully open access in January 2019, the society has announced. Both the Journal of Biomedical Optics and Neurophotonics will transition beginning with submissions received as of July 2018.

BIDMC researchers use artificial intelligence to identify bacteria quickly and accurately

(Beth Israel Deaconess Medical Center) Microscopes enhanced with artificial intelligence (AI) could help clinical microbiologists diagnose potentially deadly blood infections and improve patients' odds of survival, according to microbiologists at Beth Israel Deaconess Medical Center (BIDMC).

Amber-tinted glasses may provide relief for insomnia

(Columbia University Medical Center) Researchers from Columbia University Medical Center tested a method to reduce the adverse effects of evening ambient light exposure, while still allowing use of blue light-emitting devices.

What does hair loss have to teach us about cancer metastasis?

(Medical University of South Carolina) Researchers at the Medical University of South Carolina have identified a signaling pathway regulating cell migration and metastasis. Unexpected hair loss in a preclinical model helped them to identify the pathway. When cells within the skin that maintain hair follicles migrate too often, hair follicle maintenance is disrupted. Researchers speculated that this pathway might also play a role in cancer cell migration. Indeed, they showed that disrupting this pathway in preclinical models increased metastasis.

Nanodiscs catch misfolding proteins red-handed

(University of Michigan) When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers, including University of Michigan biophysicists, have obtained a structural snapshot of these proteins when they are most toxic, detailing them down to the atomic level.

AGS remains deeply troubled by tax reform bill and its impact on older Americans

(American Geriatrics Society) The American Geriatrics Society (AGS) continues to voice strong opposition to the Tax Cuts and Job Acts, the tax reform bill that could jeopardize care for millions of older adults and caregivers if it passes a Congressional vote planned for early next week.

Innovation Accelerator program announces support for four projects improving health care

(University of Pennsylvania School of Medicine) Penn Medicine's Innovation Accelerator Program, now in its fifth year, has announced funding for four new projects aimed at addressing disparities to improve health care delivery and patient outcomes. The program, operated by the Penn Medicine Center for Health Care Innovation, supports proposals from University of Pennsylvania Health System faculty and staff, based on their insights into opportunities to achieve high value care.

Could a new app help cure loneliness?

(Lancaster University) Researchers from Lancaster University are exploring whether technology could be the key to tackling the UK's loneliness epidemic by better connecting older adults with their communities.

Genetic instructions from mom set the pattern for embryonic development

(Princeton University) A new study indicates an essential role for a maternally inherited gene in embryonic development. The study found that zebrafish that failed to inherit specific genetic instructions from mom developed fatal defects earlier in development, even if the fish could make their own version of the gene.