KIDNEY / NEPHROLOGY NEWS

STUDY EXAMINES VOLUME OVERLOAD IN PATIENTS INITIATING PERITONEAL DIALYSIS

Volume overload, or too much fluid in the body, is a frequent problem in patients with kidney failure initiating peritoneal dialysis. Volume overload tends to improve over time after starting peritoneal dialysis, but is consistently higher in males vs. females and in patients with diabetes vs. those without. Volume overload is associated with a higher risk of premature death.

Insulin under the influence of light

By understanding how the brain links the effects of insulin to light, researchers are deciphering how insulin sensitivity fluctuates according to circadian cycles. At the heart of their discovery are neurons of the ventromedial hypothalamic nucleus, a part of the brain that masters this balance. These results should also encourage diabetic patients to consider the best time to take insulin to properly control its effect and limit the risk of hypoglycemia.

Vascularized Kidney Tissue Engineered by WFIRM Scientists

Wake Forest Institute for Regenerative Medicine (WFIRM) researchers have shown the feasibility of bioengineering vascularized functional renal tissues for kidney regeneration, developing a partial augmentation strategy that may be a more feasible and practical approach than creating whole organs.

Genomic collision may explain why many kidney transplants fail

Up to one in seven kidney donors and recipients may have a type of genetic incompatibility that leads to organ rejection, researchers have found.

Hopkins-Led Team Finds Biomarkers to Diagnose Serious Kidney Allergic Reaction

Newswise imageA team led by Johns Hopkins Medicine researchers says it has identified two protein biomarkers in urine that may one day be used to better diagnose acute interstitial nephritis (AIN), an underdiagnosed but treatable kidney disorder that impairs renal function in the short term and can lead to chronic kidney disease, permanent damage or renal failure if left unchecked.

New approach uses magnetic beads to treat preeclampsia

A new proof of concept study shows that functionalized magnetic beads reduced blood levels of a harmful molecule by 40%, which doubled the effect of a different molecule that aids blood vessel function, opening new perspectives for the treatment of preeclampsia.

Chronic kidney disease epidemic in agricultural workers: High heat, toxins

A mysterious epidemic of chronic kidney disease among agricultural workers and manual laborers may be caused by a combination of increasingly hot temperatures, toxins and infections, according to researchers.

Healthy plant-based diet (but not plant-based junk food) may protect kidneys

(Reuters Health) - While a healthy-plant based diet is tied to a lower risk of kidney disease, people who fill their plates with starchy, sugary vegetarian fare may actually increase their risk of kidney damage, a new study suggests.

STATEMENT OF AMERICAN SOCIETY OF NEPHROLOGY PRESIDENT MARK E. ROSENBERG, MD, FASN, ON FISCAL YEAR 2020 PROPOSED BUDGET OF $41.1 BILLION FOR THE NATIONAL INSTITUTES OF HEALTH

On behalf of the more than 40 million children, adolescents, and adults living with kidney diseases in the United States, the American Society of Nephrology (ASN) applauds the House Labor, Health and Human Services, Education, and Related Agencies Appropriations (LHHS) Subcommittee for their support of a Fiscal Year 2020 budget of $41.1 billion for the National Institutes of Health (NIH), an increase of $2 billion above the 2019 enacted level. ASN represents more than 20,000 physicians, scientists, nurses, and other health professionals dedicated to treating and studying kidney diseases to improve the lives of people with kidney diseases.

Like ‘Uber for Organs’: Drone Delivers Kidney to Maryland Woman

A team at the University of Maryland is developing drone technology to deliver organs faster and give doctors timely updates on their transit.

TMVR Benefits Hold Firm in Post-Market Registry (CME/CE)

(MedPage Today) -- Do data point to a future 'transcatheter toolbox' for mitral disease?

Multivessel PCI Not Best in Cardiogenic Shock

(MedPage Today) -- Trial data show mortality disadvantage versus treating culprit lesions only

ASN 2017: The Future of Personalized Nephrology

(MedPage Today) -- Tissue engineering, drug discovery challenges among highlight topics

10 Questions to Challenge Your Medical News Savvy

(MedPage Today) -- Weekly News Quiz: October 20-26

Surgical Weight Loss; Low hs-cTNT Still Risky; VAD Before Pediatric Transplant

(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week

EndoBreak: T1D and Vitamin D; VA's T2D Guideline; Oral Acromegaly Drug

(MedPage Today) -- News and commentary from the endocrinology world

For SAVR, Afternoon Tops Morning for Surgical Safety (CME/CE)

(MedPage Today) -- Circadian genes appear to interact with ischemia-reperfusion injury effects

Robotic-Assisted Surgery Adds Time, Costs Without Affecting Outcomes (CME/CE)

(MedPage Today) -- No improvements compared with laparoscopic procedures in kidney removal and rectal cancer

RAS Blockade After TAVI Tied to Better Outcomes (CME/CE)

(MedPage Today) -- Patients with severe aortic stenosis see reduced all-cause mortality

Borderline Pulmonary Hypertension Tied to Mortality Risk

(MedPage Today) -- Small increases in pressure might signal left heart failure, not early PAH

What causes back pain on the lower right side?

Lower back pain is a common complaint. When back pain occurs on the lower right side, causes can include sprains and strains, kidney stones, infections, and conditions that affect the intestines or reproductive organs. Learn more about what causes back pain on the lower right side and when to see a doctor here.

Scientists find possible causes for chronic kidney disease 'epidemic'

New research suggests that climate change and environmental toxins may explain the increasing prevalence of chronic kidney disease.

Causes of swollen hands

Some causes of swollen hands include pregnancy, exercise, and fluid retention. Treatment depends on the underlying issue. Learn more about possible causes of swollen hands here.

What to know about a low-protein diet

People with kidney-related illnesses may benefit from a low-protein diet. Key changes can help people create a varied, healthful, low-protein diet plan that works for them. Learn more here.

When to see a doctor for severe stomach pain

A wide range of problems and medical conditions can cause severe stomach pain, but not all of them require a visit to the doctor. Learn about the causes of severe stomach pain here.

What causes sharp stomach pain that comes and goes?

Many common problems can cause sharp stomach pain that comes and goes, including trapped gas and viruses. Learn about these and other causes in this article.

What to know about potassium deficiency symptoms

Symptoms of potassium deficiency, or hypokalemia, can include constipation, kidney problems, muscle weakness, fatigue, and heart issues. Poor diet, illnesses that cause severe vomiting or diarrhea, and certain medications can lead to low potassium levels. Learn more here.

What to know about urethral syndrome

Urethral syndrome, also known as urethral pain syndrome, can occur when the urethra becomes irritated. Symptoms can include urination difficulties and pain or discomfort in the lower abdomen. Learn more about the symptoms, risk factors, and treatment of urethral syndrome here.

Urethral stricture: Everything you need to know

Urethral stricture refers to scarring on the urethra, which is the tube that carries urine from the bladder out of the body. Learn more about urethral stricture here.

How to tell the difference between kidney pain and back pain

It can sometimes be difficult to tell the difference between back pain and kidney pain because the kidneys sit below the rib cage near the back.

HYPERTENSION NEWS

How a fruit compound may lower blood pressure

New research in mice and human cells finds that a fruit compound lowers blood pressure. The study also reveals the mechanism by which it does this.

How much coffee is too much for the heart?

In a large new study, researchers identify 'the tipping point' for consumption after which coffee can increase a person's cardiovascular risk.

Eat walnuts to lower blood pressure, new study suggests

The authors of a new study conclude that for people already at risk of cardiovascular disease, adding walnuts to a low-fat diet could lower that risk.

Can drinking mineral-rich water prevent hypertension?

A study that links drinking salinated water to lower blood pressure attributes the effect to benefits of calcium and magnesium exceeding harms of sodium.

Type 2 diabetes: Intensive hypertension therapy may lower death risk

New research finds that intensive therapy for lowering the blood pressure of people with type 2 diabetes reduces their risk of mortality.

Stress, insomnia may triple death risk for those with hypertension

New research examines the effect of work stress and trouble sleeping on the risk of cardiovascular death in people who already have high blood pressure.

What is the best time to take statins and why?

Some cholesterol-lowering drugs work best when a person takes them in the evening, while others are equally effective in the morning. Learn more about different statins, including the best time of day to take them.

5-minute breathing 'workout' may benefit heart and brain health

New research finds that using a breathing device that strengthens breathing muscles for 5 minutes can lower blood pressure and boost cognition.

What causes an abnormal EKG result?

Several situations and medical conditions can cause abnormal EKG results, including electrolyte imbalances and irregular heart rhythms. Learn more in this article.

Frequent urination at night may be a sign of hypertension

New research finds that nocturia, or the frequent need to urinate at night, may be a sign of high blood pressure. A high salt intake may also play a role.

GENERAL MEDICAL NEWS

Fournier gangrene of the genitals linked to SGLT2 inhibitor drugs

WGNTV: The study published in the Annals of Internal Medicine examined ties between sodium-glucose cotransporter-2 inhibitors, used in Type 2 diabetes treatment, and a genital infection called Fournier gangrene.

Immune cell test identifies patients with chronic fatigue syndrome.

Stanford: Researchers at the Stanford University School of Medicine have created a blood test that can flag the disease, which currently lacks a standard, reliable diagnostic test.

Candida auris infections spreading rapidly across the globe.

NY Times: A deadly, drug-resistant fungus is infecting patients in hospitals and nursing homes around the world. The fungus seems to have emerged in several locations at once, not from a single source.

Rehydrating with soft drinks after exercise increases AKI injury markers

Chapman et al, AJP, March, 2019: "Stage 1 AKI (i.e., increased serum creatinine ≥0.30 mg/dl) was detected at postexercise in 75% of participants in the Soft Drink trial compared with 8% in Water trial (P = 0.02). Furthermore, urinary neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of AKI, was higher during an overnight collection period after the Soft Drink trial compared with Water in both absolute concentration [6 (4) ng/dl vs. 5 (4) ng/dl, P < 0.04] and after correcting for urine flow rate [6 (7) (ng/dl)/(ml/min) vs. 4 (4) (ng/dl)/(ml/min), P = 0.03]." Possible mechanism implicated was fructose-mediated release of vasopressin. Of relevance to MesoAmerican nephropathy.

Universal flu vaccine on the near horizon

SBS.com: Scientists at the Doherty Institute and Monash University say they have discovered immune cells that could fight off all forms of the flu virus, which could see an end to annual flu jabs. Depending on a patient's immune system, a cover-all flu shot would only be needed every 10 years, or potentially just once in a lifetime - and could help prevent thousands of deaths worldwide every year.

Alzheimer disease linked to brain infection by gingivitis bacteria.

New Scientist: Multiple research teams have been investigating P. gingivalis, and have so far found that it invades and inflames brain regions affected by Alzheimer’s; that gum infections can worsen symptoms in mice genetically engineered to have Alzheimer’s; and that it can cause Alzheimer’s-like brain inflammation, neural damage, and amyloid plaques in healthy mice.

Bone mass increased by 800% in a mouse model

Medical News Today: A groundbreaking set of studies has found that blocking certain receptors in the brain leads to the growth of remarkably strong bones. Could a new osteoporosis treatment be on the horizon?

Harvard Intensive Review of Nephrology 2018 now available

Intensive Review of Nephrology................ Harvard Medical School and Brigham and Women's Hospital Board Review Prep for ABIM Nephrology exams, expand your knowledge and integrate the latest guidelines into your daily practice................. Video Online - $1,395.00.......... Online + USB* - $1,495.00 ...............Audio MP3s: CDs - $1,495.00 ............USB* - $1,495.00...............Combo: Online Video + Audio MP3 CDs + USB - $2,095.00.

Randomized PIVOT trial published in NEJM suggests more IV iron is better.

NEJM (Macdougall): Conclusions: Among patients undergoing hemodialysis, a high-dose intravenous iron regimen administered proactively was noninferior to a low-dose regimen administered reactively and resulted in lower doses of erythropoiesis-stimulating agent being administered.

Increased mortality with citrate-containing dialysate - HDF fluid in France.

LeMonde: (in French -- paste this link into Google translate) ...les patients traités par un liquide de dialyse (ou dialysat) au citrate présenteraient une surmortalité de 40 % par rapport à ceux traités avec d’autres produits plus anciens à l’acétate ou à l’acide chlorhydrique (HCl).........Tel est le principal constat d’une étude rétrospective pilotée par Lucile Mercadal (Inserm, CESP 1018 et hôpital Pitié-Salpêtrière) réalisée avec une équipe de néphrologues et de biostatisticiens français (REIN-Agence de la biomédecine, ABM), à partir des données du registre national REIN. Elle a été présentée le ­3 octobre lors du congrès de la Société francophone de néphrologie, dialyse et transplantation ; elle n’est pas encore publiée.

Drug-resistant infections: If you can't beat 'em, starve 'em, scientists find

(University at Buffalo) To treat Candida albicans, a common yeast that can cause illness in those with weakened immune systems, University at Buffalo researchers limited the fungus' access to iron, an element crucial to the organism's survival.

Study analyzes mortality risks among pro athletes

(Harvard Medical School) A first-of-its-kind comparison between elite pro athletes suggests higher overall mortality among NFL players compared with MLB players. NFL players also appear to have higher risk of dying from cardiovascular and neurodegenerative causes compared with MLB peers.The differences warrant further study of sport-specific mechanisms of disease development. Clinicians treating current and former NFL players should be vigilant about the presence of cardiovascular and neurologic symptoms and promptly treat risk factors such as sleep apnea, obesity, hypertension.

Technology better than tape measure for identifying lymphedema risk

(Vanderbilt University) New research by School of Nursing professor Sheila Ridner finds that a special scan measuring lymphatic fluid volume is significantly better than a tape measure at predicting which women undergoing treatment for breast cancer are at risk of developing a common complication resulting from damaged lymph nodes.

New study reveals gut is organized by function, and opportunities for better drug design

(Rockefeller University) New findings provide insights about how the intestine maximizes nutrient uptake, while at the same time protecting the body from potentially dangerous microbes.

Mobile phone app designed to boost physical activity in women shows promise in trial

(NIH/National Heart, Lung and Blood Institute) Funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, the study is one of the first to examine how an app-based program can help increase and maintain objectively measured daily physical activity. It was published online on May 24 in JAMA Network Open, a peer-reviewed online-only journal.

Researchers discover how three-dimensional organization of the genome regulates cell differentiation

(University of Minnesota Medical School) A new study from the University of Minnesota Medical School clarifies how the three-dimensional organization of the genome is regulated at the onset of skeletal muscle formation.

Cancer cells are quick-change artists adapting to their environment

(Luxembourg Institute of Health) Until now, researchers have assumed that the growth of solid tumors originates from cancer stem cells characterized by specific surface markers, which develop in a fixed, hierarchical order. In a joint interdisciplinary project led by the Luxembourg Institute of Health (LIH), researchers now show that cancer cells of glioblastomas -- conspicuously aggressive solid brain tumors -- manifest developmental plasticity and their phenotypic characteristics are less constrained than believed.

Insilico to present at the 2019 Innovative China Conference

(InSilico Medicine, Inc.) Insilico to present its research at the Bank of America Merrill Lynch's 4th Innovative China Conference.

Gene therapy towards a clinical trial for gamma-sarcoglycanopathy, limb-girdle muscular dystrophy

(AFM-Téléthon) Isabelle Richard's team, a CNRS researcher in an Inserm unit at Genethon, the AFM-Telethon laboratory, has demonstrated the efficacy of gene therapy and determined the effective dose for treating a rare muscle disease, gamma-sarcoglycanopathy, in mouse models of the disease. Based on these encouraging results, published in Molecular Therapy: Methods and Clinical Development, the researchers are preparing a clinical trial.

Do you hear what I hear?

(Columbia University Irving Medical Center) A new study by Columbia University researchers found that infants at high risk for autism were less attuned to differences in speech patterns than low-risk infants. The findings suggest that interventions to improve language skills should begin during infancy for those at high risk for autism.