KIDNEY / NEPHROLOGY NEWS

Using genetics of human fat cells to predict response to anti-diabetes drugs

Researchers have demonstrated -- using fat cells derived from human stem cells -- that individual genetic variation can be used to predict whether the TZD rosiglitazone will produce the unwanted side effect of increasing cholesterol levels in certain individuals.

Excessive body fat around the middle linked to smaller brain size, study finds

Carrying extra body fat, especially around the middle, may be linked to brain shrinkage, according to new research. For the study, researchers determined obesity by measuring body mass index (BMI) and waist-to-hip ratio in study participants and found those with higher ratios of both measures had the lowest brain volume.

Spirulina: Could eating these bacteria reduce blood pressure?

Spirulina — a blue-green algae used as a supplement — appears to reduce blood pressure. A recent study pins down the molecular mechanisms involved.

PERITONEAL DIALYSIS TRIALS OFTEN DO NOT ASSESS PRIORITIES MOST IMPORTANT TO PATIENTS

Patients on peritoneal dialysis and their caregivers give high priority to clinical outcomes (such as infection and mortality) and many patient-reported outcomes (particularly fatigue and flexibility with time), which are absent in most trials in peritoneal dialysis.

SUGAR-SWEETENED BEVERAGE PATTERN LINKED TO HIGHER KIDNEY DISEASE RISK

In a study of African-American men and women with normal kidney function, a pattern of higher collective consumption of soda, sweetened fruit drinks, and water was associated with a higher risk of developing kidney disease.

In older people, type 2 diabetes is associated with a decline in brain function over 5 years, study shows

New research shows that in older people living in the community, type 2 diabetes is associated with a decline in verbal memory and fluency over five years.

STUDY COMPARES DIALYSIS REIMBURSEMENT AROUND THE GLOBE

Dialysis reimbursement policies in most countries are focused on conventional in-center hemodialysis, although home hemodialysis and peritoneal dialysis might contribute to quality of life and cost savings. The reimbursement for dialysis in low- and middle-income countries is insufficient to treat all patients with kidney failure and has a disproportionately high impact on public health expenditure in those countries

Diabetic amputations on the rise in the U.S.

(Reuters Health) - - A growing number of people with diabetes in the U.S. are losing toes and feet to the disease by the time they reach middle age, according to a study that suggests a reversal after years of progress against diabetes.

Christmas Is a Peak Time for Heart Attacks

In Sweden, Christmas Eve, Christmas Day and New Year’s Day were prime times for heart troubles.

Statins: Risk of side effects is low, say experts

For most people at risk of heart attack and stroke, using statins to lower cholesterol brings more benefits than risks, say the American Heart Association.

TMVR Benefits Hold Firm in Post-Market Registry (CME/CE)

(MedPage Today) -- Do data point to a future 'transcatheter toolbox' for mitral disease?

Multivessel PCI Not Best in Cardiogenic Shock

(MedPage Today) -- Trial data show mortality disadvantage versus treating culprit lesions only

ASN 2017: The Future of Personalized Nephrology

(MedPage Today) -- Tissue engineering, drug discovery challenges among highlight topics

10 Questions to Challenge Your Medical News Savvy

(MedPage Today) -- Weekly News Quiz: October 20-26

Surgical Weight Loss; Low hs-cTNT Still Risky; VAD Before Pediatric Transplant

(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week

EndoBreak: T1D and Vitamin D; VA's T2D Guideline; Oral Acromegaly Drug

(MedPage Today) -- News and commentary from the endocrinology world

For SAVR, Afternoon Tops Morning for Surgical Safety (CME/CE)

(MedPage Today) -- Circadian genes appear to interact with ischemia-reperfusion injury effects

Robotic-Assisted Surgery Adds Time, Costs Without Affecting Outcomes (CME/CE)

(MedPage Today) -- No improvements compared with laparoscopic procedures in kidney removal and rectal cancer

RAS Blockade After TAVI Tied to Better Outcomes (CME/CE)

(MedPage Today) -- Patients with severe aortic stenosis see reduced all-cause mortality

Borderline Pulmonary Hypertension Tied to Mortality Risk

(MedPage Today) -- Small increases in pressure might signal left heart failure, not early PAH

Uses and types of urinary catheter

A person may need to use a urinary catheter if they have problems passing urine. There are several types of catheter, each with its own advantages and disadvantages. Learn more about urinary catheters, and what to expect when using them, here.

Remedios caseros para la vaginosis bacteriana

La vaginosis bacteriana es la infección vaginal más común. ¿Qué la causa, funcionan los remedios caseros? En este artículo responderemos estas preguntas y más.

Trece remedios caseros y naturales para los cálculos renales

Los cálculos renales se producen cuando los minerales y las sales forman depósitos duros en los riñones. A continuación, veremos 13 remedios caseros para ayudar a controlar los síntomas.

Causes of abdominal pain and chills

The causes of stomach pain and chills include gastroenteritis, salmonella, and even the common cold. Treatment depends on the cause. Learn more about these, and the other causes of stomach pain and chills, here.

Abdominal pain and painful urination causes

Pain in the abdomen and pain while urinating can result from a range of issues, including a urinary tract infection. Learn more about the potential causes here.

What is bowel obstruction?

A bowel obstruction occurs when something blocks part of the small or large intestine. This blockage can be a serious problem if it is left untreated, so a person should speak to a doctor if they experience any of the symptoms. Learn more about these symptoms, the causes, treatment options, and diet tips here.

What is the normal pH range for urine?

The acidity of urine varies greatly depending on a person’s diet and any medical conditions they may have. In this article, we discuss the normal pH range for urine, and what abnormal test results might mean.

Can D-mannose treat a UTI?

D-mannose is a type of sugar that researchers believe may help treat urinary tract infections (UTIs). Learn more about the studies, conclusions, and possible dosage here.

What are the symptoms of low sodium levels?

Low sodium in the blood can cause confusion, lethargy, and nausea. Treatment depends on the cause. Learn more about low sodium levels, risk factors, prevention and treatment here.

What are the most common causes of pelvic pain in men?

Pelvic pain in men can result from a range of issues, including a hernia, prostatitis, and appendicitis. This pain occurs somewhere between the navel and groin. Treatment depends on the cause and may involve antibiotics. Learn about the most common causes of pelvic pain in men here.

HYPERTENSION NEWS

Metoprolol tartrate vs. metoprolol succinate

Metoprolol tartrate and metoprolol succinate are different salt forms of metoprolol. Both drugs are beta-blockers that doctors prescribe to treat several cardiovascular conditions. However, despite being similar, they do have some different uses. Learn more here.

Health benefits of mung beans

Mung beans are a healthful source of protein, fiber, vitamins, and minerals. Some research also suggests that they may have a range of other health benefits. Learn more here.

Spirulina: Could eating these bacteria reduce blood pressure?

Spirulina — a blue-green algae used as a supplement — appears to reduce blood pressure. A recent study pins down the molecular mechanisms involved.

Can exercise lower blood pressure as effectively as drugs?

The most common treatment for high blood pressure consists of taking specific medication, but could regular exercise bring the same benefits?

What are the benefits of spirulina?

Spirulina is blue-green algae often hailed as a superfood. It contains many key nutrients and may have wide-ranging benefits, including for blood pressure, diabetes, and removing toxic chemicals from the body. Learn more about the benefits of spirulina here.

Losartan potassium: Uses and warnings

Losartan potassium is a drug that effectively treats high blood pressure and diabetic neuropathy. This article provides an overview of the benefits, effectiveness, side effects, and warnings associated with losartan potassium.

How can you tell when you have high blood pressure?

High blood pressure causes no symptoms until it becomes severe. In this article, we discuss the myths and truths of high blood pressure symptoms. We also look at how to tell when blood pressure is too high and how to interpret blood pressure readings.

What to know about high blood pressure during pregnancy

A doctor should monitor high blood pressure (hypertension) during pregnancy to prevent complications for the mother, such as preeclampsia, and the baby. High blood pressure is usually treatable and preventable. Learn about the types, causes, and treatments of high blood pressure during pregnancy here.

Blood pressure medications: Everything you need to know

Blood pressure medications help prevent many serious complications, such as stroke and heart disease. Learn about the types and possible side effects in this article.

Could blue light reduce blood pressure?

According to recent findings, exposing the body to blue light could lower high blood pressure as effectively as taking hypertension medication.

GENERAL MEDICAL NEWS

Bone mass increased by 800% in a mouse model

Medical News Today: A groundbreaking set of studies has found that blocking certain receptors in the brain leads to the growth of remarkably strong bones. Could a new osteoporosis treatment be on the horizon?

Harvard Intensive Review of Nephrology 2018 now available

Intensive Review of Nephrology................ Harvard Medical School and Brigham and Women's Hospital Board Review Prep for ABIM Nephrology exams, expand your knowledge and integrate the latest guidelines into your daily practice................. Video Online - $1,395.00.......... Online + USB* - $1,495.00 ...............Audio MP3s: CDs - $1,495.00 ............USB* - $1,495.00...............Combo: Online Video + Audio MP3 CDs + USB - $2,095.00.

Randomized PIVOT trial published in NEJM suggests more IV iron is better.

NEJM (Macdougall): Conclusions: Among patients undergoing hemodialysis, a high-dose intravenous iron regimen administered proactively was noninferior to a low-dose regimen administered reactively and resulted in lower doses of erythropoiesis-stimulating agent being administered.

Increased mortality with citrate-containing dialysate - HDF fluid in France.

LeMonde: (in French -- paste this link into Google translate) ...les patients traités par un liquide de dialyse (ou dialysat) au citrate présenteraient une surmortalité de 40 % par rapport à ceux traités avec d’autres produits plus anciens à l’acétate ou à l’acide chlorhydrique (HCl).........Tel est le principal constat d’une étude rétrospective pilotée par Lucile Mercadal (Inserm, CESP 1018 et hôpital Pitié-Salpêtrière) réalisée avec une équipe de néphrologues et de biostatisticiens français (REIN-Agence de la biomédecine, ABM), à partir des données du registre national REIN. Elle a été présentée le ­3 octobre lors du congrès de la Société francophone de néphrologie, dialyse et transplantation ; elle n’est pas encore publiée.

Test detects presence of cancer in blood samples based on DNA methylation.

Medical Device Network: Researchers at University of Queensland in Australia have created a new diagnostic test that can identify the presence of a tumour in the body based on a unique, DNA nanostructure that appears to be common to all types of cancer.

Akkermansia gut bacteria and their role in insulin resistance and aging.

Orlando Sentinel: First, they documented that the guts of older animals had markedly smaller populations of A. muciniphila than the guts of young animals, and that as A. muciniphila became more scarce, so did butyrate, one of the gut’s key protectors. The deficiency of these two substances caused the mucous walls of the of the aged animals’ intestines to thin and grow leaky. That corrosive process unleashed a chain of events that touched off inflammation, prompted an immune response and, in a final step, increased insulin resistance.

KidneyX prize competition now open: Application deadline Feb 28, 2019

Phase 1 submission period open now..................... Phase 1 submission period ends: February 28, 2019, 5:00 p.m. ET.............. Phase 1 Awardees announced by: April 30, 2019............................. Phase 2 begins: April 15, 2019................................... In Phase 1, we are looking for designs of solutions that will address at least one of the following areas:......................... Replicating Kidney Functions (Blood Filtration, Electrolyte Homeostasis, Fluid Regulation, Toxin Removal and Secretion, and/or Filtrate Drainage and Connectivity).................................. Improving Patient Quality of Life (e.g., minimizing burden on the family and care partner(s), reducing disease and treatment complications, increasing mobility and physical activity)...................................... Improved renal replacement therapy access (vascular or peritoneal access) Addressing engineering challenges (e.g., preventing clotting, bleeding, and infection in vascular circuit and associated devices)............................ Ancillary technologies................... Biomaterials development.................... Biological and Immunological modulation..................... Biosensor development and other safety monitoring functions................

AKI and CRRT 2019 Conference, Feb 26 -- March 1, 2019, San Diego, CA

The learning objectives for this conference are as follows: 1. Describe the recent advances in the pathophysiology and management of critically ill patients with a focus on sepsis, multi-organ failure, infections, lung and kidney injury in different settings..................................... 2. Discuss the best ways to identify, treat and follow up patients with acute kidney injury (AKI) resulting from different causes utilizing biomarkers, imaging and lab studies and applying educational tools to raise awareness of AKI......................... 3. Describe the principles and practice of renal replacement techniques including CRRT, IHD and plasma exchange and demonstrate how to setup and use these techniques for managing critically ill patients.

Donate to easy water for African villages using hollow-fiber technology

Easy water: Providing clean drinking water in rural areas with contaminated water sources and no power: repurposing reprocessed hemodialyzers. Easy Water for Everyone (EWfE), a US NGO, brings an innovative water-purifying device to isolated villages that have no electricity or other power supply to filter the villages’ contaminated water from rivers, streams, lakes, wells and boreholes, and changes it into pure water ready to drink!

Recovery from coma predicted by artificial intelligence and eye scans.

South China Morning Post: At least seven patients in Beijing who doctors said had “no hope” of regaining consciousness were re-evaluated by an artificial intelligence system that predicted they would awaken within a year.

Research reveals mechanism for leukaemia cell growth, prompting new treatment hopes

(University of Sussex) A mechanism which drives leukaemia cell growth has been discovered by researchers at the University of Sussex, who believe their findings could help to inform new strategies when it comes to treating the cancer.

U develops first dark sky studies minor in the US

(University of Utah) The W. M. Keck Foundation has awarded $250,000 to the University of Utah to establish a new undergraduate minor in dark sky studies, the first of its kind in the United States. The minor is open to all students across the university who will explore issues through the lens of science, humanities, arts, and participate in field-based research.

New yeast model of metabolic disorders may lead to life-saving therapies

(American Friends of Tel Aviv University) A new Tel Aviv University study suggests that the role of yeast, the world's most basic eukaryotic unicellular organism, may pave the way for the development of novel, more effective therapies for congenital diseases.

First international consensus on fibromuscular dysplasia

(SAGE) The "First international consensus on the diagnosis and management of fibromuscular dysplasia" (FMD) has been published online first today in Vascular Medicine and the Journal of Hypertension.

The story of a successful surgical revolution

(Springer) In the late 1950s, the treatment for fractures involved three to four months in hospital in plaster-casts and traction. Recovery was slow, and up to 70 percent of patients experienced reduced mobility upon recovery.

New AI can detect urinary tract infections

(University of Surrey) New AI developed at the University of Surrey could identify and help reduce one of the top causes of hospitalisation for people living with dementia: urinary tract infections (UTI).

Engineered light to improve health, food, suggests Sandia researcher in Nature

(DOE/Sandia National Laboratories) intentionally controlled light can help regulate human health and productivity by eliciting various hormonal responses. Tailored LED wavelengths and intensities also can efficiently stimulate plant growth, alter their shapes and increase their nutritional value, opening a new world of scientific and technological possibilities for indoor farming.

NSF grant: Machine learning to decrease brain injury deaths

(Virginia Tech) "Our research is especially important because it goes beyond general possibilities to the more specific ones," Reddy said.

Combatting brain infections in special issue of Viral Immunology

(Mary Ann Liebert, Inc./Genetic Engineering News) A special issue of Viral Immunology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, contains a rich collection of the latest research and reviews focusing on Viral Neuroimmunology and the intricacies of viral brain infection.

Fighting perinatal mood and anxiety disorders on multiple levels

(Children's National Health System) An award-winning poster that Lenore Jarvis, M.D., MEd, and colleagues presented at the American Academy of Pediatrics National Convention and Exhibit in Orlando, Florida, details Children's integrated approach to help women with perinatal mood and anxiety disorders which includes actions at individual, interpersonal, organizational, community and policy levels.