KIDNEY / NEPHROLOGY NEWS

Genetic factors tied to obesity may protect against diabetes

Some genetic variations associated with obesity actually protect against Type 2 diabetes, heart attack and stroke, new findings suggest.

PCR Test Bests Urine Cultures for UTI Pathogen Detection

A multiplex polymerase chain reaction assay detected bacteria species missed by traditional urine culture as well as more fastidious bacteria.

RAS Inhibitor Therapy May Prolong Survival After Acute Kidney Injury

In a Canadian study of patients who experienced AKI during hospitalization, treatment with an ACEI or ARB within 6 months of discharge was associated with a 15% lower risk for death after 2 years.

STUDY POINTS TO INSURANCE-RELATED DISPARITIES IN TIMELY ACCESS TO GOLD STANDARD DIALYSIS PROCEDURE

Kidney failure patients without Medicare at the time of diagnosis experience delays in obtaining arteriovenous fistulas and grafts.

Febuxostat Increases CV Event Risk Only in Established CV Disease

Spanish study found no significant difference between febuxostat and allopurinol with respect to risk of new cardiovascular events among gout patients without prior cardiovascular disease.

THE AMERICAN SOCIETY OF NEPHROLOGY HONORS LEADERS IN THE FIGHT AGAINST KIDNEY DISEASES

Educational innovators and preeminent researchers are among the five leaders to be honored at ASN Kidney Week 2018

Robotic Tumor Enucleation Appears Safe for Sporadic Renal Cell Carcinoma

Long-term oncologic outcomes of patients with sporadic RCC who underwent robotic tumor enucleation suggest the procedure is safe.

Gout Outcomes Better With Nurse-Led Care

In a British study, nurse-led care emphasizing patient education and engagement significantly improved the proportion of gout sufferers who achieved target serum urate levels.

QUALITY OF PATIENT EXPERIENCE WITH DOCTORS MAY AFFECT HOSPITALIZATION RISK IN HISPANICS WITH KIDNEY DISEASE

Lower perceived quality of patient-physician interaction was associated with a higher risk of hospitalization in Hispanics with chronic kidney disease. Quality of patient-physician interaction was not associated with risk of developing kidney failure or dying.

High-Dose Influenza Vaccination May Benefit Transplant Recipients

Double-dose influenza vaccine is safe and may increase antibody response in solid-organ transplant recipients

TMVR Benefits Hold Firm in Post-Market Registry (CME/CE)

(MedPage Today) -- Do data point to a future 'transcatheter toolbox' for mitral disease?

Multivessel PCI Not Best in Cardiogenic Shock

(MedPage Today) -- Trial data show mortality disadvantage versus treating culprit lesions only

ASN 2017: The Future of Personalized Nephrology

(MedPage Today) -- Tissue engineering, drug discovery challenges among highlight topics

10 Questions to Challenge Your Medical News Savvy

(MedPage Today) -- Weekly News Quiz: October 20-26

Surgical Weight Loss; Low hs-cTNT Still Risky; VAD Before Pediatric Transplant

(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week

EndoBreak: T1D and Vitamin D; VA's T2D Guideline; Oral Acromegaly Drug

(MedPage Today) -- News and commentary from the endocrinology world

For SAVR, Afternoon Tops Morning for Surgical Safety (CME/CE)

(MedPage Today) -- Circadian genes appear to interact with ischemia-reperfusion injury effects

Robotic-Assisted Surgery Adds Time, Costs Without Affecting Outcomes (CME/CE)

(MedPage Today) -- No improvements compared with laparoscopic procedures in kidney removal and rectal cancer

RAS Blockade After TAVI Tied to Better Outcomes (CME/CE)

(MedPage Today) -- Patients with severe aortic stenosis see reduced all-cause mortality

Borderline Pulmonary Hypertension Tied to Mortality Risk

(MedPage Today) -- Small increases in pressure might signal left heart failure, not early PAH

What to know about gallbladder removal

A doctor may recommend gallbladder removal if other treatments do not provide relief from the symptoms of gallstones. Learn about the procedure and recovery here.

Anticholinergic drugs: What to know

Anticholinergic drugs can help treat a variety of conditions, including chronic obstructive pulmonary disease, bladder conditions, gastrointestinal disorders, and symptoms of Parkinson’s disease. In this article, learn about the different types of anticholinergic drugs and their possible side effects.

'Anti-aging molecule' could improve liver and kidney treatments

Blocking an enzyme that limits the activity of the 'anti-aging molecule' NAD+ could be a way to protect the liver and kidneys from damage, study suggests.

Can you take too much magnesium?

Magnesium is essential for health, but taking too much can cause problems, including digestive issues, lethargy, and an irregular heartbeat. In rare cases, an overdose can be fatal. Learn more here.

What can make urination painful?

There are many possible causes of painful urination, or dysuria, including bacterial infections and health conditions that place extra pressure on the bladder. Fortunately, most of these potential causes are highly treatable. Learn more about 10 causes of dysuria here, as well as when to see a doctor.

Study overturns what we know about kidney stones

New research uses cutting-edge technology to study kidney stones. The findings change what we know about their nature, composition, and behavior.

Treating urinary tract infections with Cipro

Cipro is an antibiotic that doctors use to treat urinary tract infections (UTIs). For Cipro to work, people must take the full course of the drug and follow their doctor's instructions. But some people may be at risk of severe side effects if they take Cipro, and they may need to consider alternatives. Learn more here.

Urologic conditions lead to depression, sleep issues in men

Physicians need to be aware that men with urologic conditions often have depression and sleep problems and should refer them appropriately, says a study.

Vitamin B-3 may treat and prevent acute kidney injury

New research shows that raising vitamin B-3 levels may benefit patients who have undergone major surgery and are at risk of developing acute kidney injury.

What are the symptoms of a UTI in older adults?

Urinary tract infections (UTIs) can affect people at any age. However, UTIs are one of the most common causes of infection in older adults. Symptoms of a UTI in older adults may include restlessness, agitation, and confusion. UTIs are treatable with medication. Learn more about UTIs in seniors here.

HYPERTENSION NEWS

Could blue light reduce blood pressure?

According to recent findings, exposing the body to blue light could lower high blood pressure as effectively as taking hypertension medication.

What are the limitations of BMI?

A person can use their body mass index (BMI) to determine whether they have a healthful weight. But, BMI does not take certain factors into account, such as the proportion of fat to muscle. Learn more here.

What is obesity and what causes it?

Obesity is when a person is carrying excessive weight. This puts them at a higher risk of a number of health conditions. Find out more about what obesity is and why it happens.

Common drug may increase lung cancer risk

According to a recent study, a common drug used to treat blood pressure might increase the risk of lung cancer when it is taken over a long period of time.

How much should I weigh? Ways of measuring

What is a person’s ideal weight, and how do height, age, and other factors affect it? Find out more and use our tools to get a better idea of how much you should weigh.

This unlikely culprit may cause drug-resistant high blood pressure

A study of 475 male veterans with hypertension links higher lead buildup in shin bone to increased risk of drug-resistant high blood pressure.

High blood pressure control with 'exercise in a pill'

Increased body levels of a compound that the liver makes could control high blood pressure without having to exercise or eat less salt, study suggests.

What is perindopril?

Perindopril is an oral tablet used to treat hypertension (high blood pressure). It’s also used to lower the risk of death or heart attack in people with stable coronary artery (heart) disease. Perindopril is available only as a generic drug. Learn about side effects, warnings, dosage, and more.

High blood pressure breakthrough: Over 500 genes uncovered

The world's largest genetic study of hypertension finds that the number of genetic loci involved is three times larger than previously thought.

Inhaled blood pressure drug could prevent panic attacks

New research suggests that a drug commonly used for hypertension could be used as a quick-acting nasal spray to prevent anxiety attacks.

GENERAL MEDICAL NEWS

AKI and CRRT 2019 Conference, Feb 26 -- March 1, 2019, San Diego, CA

The learning objectives for this conference are as follows: 1. Describe the recent advances in the pathophysiology and management of critically ill patients with a focus on sepsis, multi-organ failure, infections, lung and kidney injury in different settings..................................... 2. Discuss the best ways to identify, treat and follow up patients with acute kidney injury (AKI) resulting from different causes utilizing biomarkers, imaging and lab studies and applying educational tools to raise awareness of AKI......................... 3. Describe the principles and practice of renal replacement techniques including CRRT, IHD and plasma exchange and demonstrate how to setup and use these techniques for managing critically ill patients.

Donate to easy water for African villages using hollow-fiber technology

Easy water: Providing clean drinking water in rural areas with contaminated water sources and no power: repurposing reprocessed hemodialyzers. Easy Water for Everyone (EWfE), a US NGO, brings an innovative water-purifying device to isolated villages that have no electricity or other power supply to filter the villages’ contaminated water from rivers, streams, lakes, wells and boreholes, and changes it into pure water ready to drink!

Recovery from coma predicted by artificial intelligence and eye scans.

South China Morning Post: At least seven patients in Beijing who doctors said had “no hope” of regaining consciousness were re-evaluated by an artificial intelligence system that predicted they would awaken within a year.

European funders ban publication in paywall-protected scientific journals.

Science (Martin Enserink): Frustrated with the slow transition toward open access (OA) in scientific publishing, 11 national funding organizations in Europe turned up the pressure today. As of 2020, the group, which jointly spends about €7.6 billion on research annually, will require every paper it funds to be freely available from the moment of publication.

CRISPR treatment halts muscular dystrophy in dogs.

WIRED: His team prepared for the worst -- ”anaphylaxis, liver toxicity, an inflammatory immune response” but in the end they saw no adverse effects. Instead they saw puppies who could play again.

Bacteria becoming tolerant to high concentrations of alcohol in hand sanitizers.

NPR: "To our knowledge this was the first time anyone had shown hospital bacteria becoming tolerant to alcohols," says Timothy Stinear, a coauthor of the study and a researcher at the University of Melbourne's Doherty Institute for Infection and Immunity.

Pharmacologic approach to weight loss that prevents food absorption.

UPI (Allen Cone): "We envision a pill that a patient can take before a meal that transiently coats the gut to replicate the effects of surgery," co-senior author Dr. Jeff Karp, a bioengineer and principal investigator at BWH, said. "Over the last several years, we've been working with our surgical colleagues on this idea and have developed a material that meets an important clinical need." Researchers are now testing LuCl in diabetic and obese rodents, measuring it's short- and long-term effects as an alternative to gastric bypass.

NKF 2018 Spring Clinical Meeting abstracts (.pdf)

NKF Spring Clinical Meeting 2018 abstracts

ERA-EDTA Copenhagen meeting newsletters

ERA-EDTA: Links can be found here to the initial 3 post-congress newsletters, as well as to the accepted abstracts.

CDC issues alert re warfarin coagulopathy and synthetic cannabinoids

CDC: What Do Health Care Providers Need To Do? ............ Healthcare providers should maintain a high index of suspicion for vitamin K-dependent antagonist coagulopathy in patients with a history of synthetic cannabinoids (e.g., K2, Spice, and AK47) use:.................Presenting with clinical signs of coagulopathy, bleeding unrelated to an injury, or bleeding without another explanation; some patients may not divulge use of synthetic cannabinoids...................Presenting with complaints unrelated to bleeding (e.g., appendicitis).

Insufficient sleep in children is associated with poor diet, obesity and more screen time

(American Academy of Sleep Medicine) A new study conducted among more than 177,000 students suggests that insufficient sleep duration is associated with an unhealthy lifestyle profile among children and adolescents.

From beaker to solved 3D structure in minutes

(California Institute of Technology) A new method for learning the structures of small molecules, such as hormones, is 'like science fiction.'

Beneficial gut bacteria metabolize fiber to improve heart health in mice

(University of Wisconsin-Madison) In support of a microbial connection between fiber and heart health, researchers at the University of Wisconsin-Madison have identified a particular fatty acid as the mechanism behind certain protective effects of a high-fiber diet in a mouse model. Known as butyrate, this fatty acid is produced by certain bacteria in the gut as they digest plant fiber.

Researchers identify risk factors of advanced liver disease in cystic fibrosis patients

(Children's Hospital Colorado) Children's Hospital Colorado (Children's Colorado) pediatric gastroenterologist, Michael Narkewicz, MD, recently shared results of the Prospective Study of Ultrasound to Predict Hepatic Cirrhosis in Cystic Fibrosis (PUSH), which sought to determine if liver ultrasounds could identify children and adolescents with cystic fibrosis who are at greater risk of developing advanced liver disease.

Key takeaways from three landmark heart studies

(Cedars-Sinai Medical Center) New findings about sudden cardiac arrest, one of medicine's biggest mysteries, were revealed at the American Heart Association Scientific Sessions.

Patients with common heart failure more likely to have lethal heart rhythms

(Cedars-Sinai Medical Center) New Smidt Heart Institute Research shows that patients with Heart Failure with Preserved Ejection Fraction (HFpEF) are more likely to have lethal heart rhythms.

COPD patients rarely receive pulmonary rehabilitation despite its health benefits

(American Thoracic Society) Only a tiny fraction of patients hospitalized for COPD, or chronic obstructive pulmonary disease, participate in a pulmonary rehabilitation program following hospitalization, even though such programs are recommended and Medicare covers their cost, according to new research published online in the Annals of the American Thoracic Society.

Obesity both feeds tumors and helps immunotherapy kill cancer

(University of California - Davis Health) A groundbreaking new study by UC Davis researchers has uncovered why obesity both fuels cancer growth and allows blockbuster new immunotherapies to work better against those same tumors.

How pneumococci challenge our immune system

(Karolinska Institutet) Pneumococci are the most common cause of respiratory tract infections, such as otitis and sinusitis, as well as of severe infections like pneumonia and meningitis. A new study from Karolinska Institutet in Sweden published in Nature Microbiology shows how the bacteria can inhibit immune cell reaction and survive inside cells to give rise to pneumonia.

New insights into the aging brain

(Gladstone Institutes) A group of scientists at the Gladstone Institutes investigated why the choroid plexus contains so much more klotho than other brain regions. In a new study published in the scientific journal PNAS, they showed that klotho functions as a gatekeeper that shields the brain from the peripheral immune system.