KIDNEY / NEPHROLOGY NEWS

Blood pressure medication does not completely restore vascular function

Treatments for high blood pressure do not totally reverse its damaging effects on the vascular rhythms that help circulation of the blood say researchers.

Serum Uromodulin May Predict CKD Development

Uromodulin may be a novel predictive serum biomarker.

Resistance to RAAS Inhibitors Not Easily Improved

Patients who show a poor response to a certain dose and medication also show a poor response to higher doses and other RAAS inhibitors or NSAIDs, meta-analysis shows.

RCC Subtypes Affect Post-Surgery Cancer-Related Mortality Risk

Patients with papillary versus clear cell renal cell carcinoma have a 24% decreased risk of dying from their cancer.

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

Researchers report a high rate of sustained virologic response after 12 weeks of treatment with a ribavirin-free co-formulation of glecaprevir and pibrentasvir.

Ask Well: How Do People Die From Diabetes?

While untreated diabetes itself can be deadly, complications from the disease such as heart attacks are a more common cause of death.

FEW PATIENTS HOSPITALIZED WITH ACUTE KIDNEY INJURY RECEIVE RECOMMENDED FOLLOW-UP CARE

Most surveyed Canadian kidney specialists recommended follow-up kidney evaluations for the majority of patients hospitalized with acute kidney injury. Real-world practice showed that only a minority of such patients in Alberta currently receive follow-up with a kidney specialist.

New type of diabetes caused by a genetic mutation

Scientific research has led to the identification of a new type of diabetes caused by a mutation in the gene RFX6.

CKD Risk Lower With Partial Nephrectomy

In a study, partial nephrectomy was associated with a 66% lower risk for stage 4 or higher CKD versus radical nephrectomy.

Low Protein Diet With Keto Analogues May Prevent SHPT

Dialysis patients treated with a low protein diet with keto analogues had lower levels of parathyroid hormone than those on a normal diet, meta-analysis shows.

Will Semaglutide Fly with FDA Advisors?

(MedPage Today) -- Increased retinopathy risk in one trial could stymie approval

Once-Daily Oral GLP-1 Comparable to Once-Weekly Injections (CME/CE)

(MedPage Today) -- Phase II study reported similar HbA1c reductions and weight loss

TAVR Speeds Downward Spiral in Advanced CKD (CME/CE)

(MedPage Today) -- Researchers pin down apparent 'tipping point' in outcomes

Early Statin in Stroke; 'Chinese Finger Trap' Valve; Disasters Hurt Vasculature, Too

(MedPage Today) -- Recent developments of interest in cardiovascular medicine

Gestational Diabetes Ups Long-Term CVD Risk (CME/CE)

(MedPage Today) -- But not among women with healthy lifestyles

PodMed: A Medical News Roundup From Johns Hopkins (with audio)

(MedPage Today) -- This week's topics include predicting mortality in those with congestive heart failure, bystander CPR impact, best management of stable COPD, and NOACs and bleeding risk

EndoBreak: Bill Passes for National Diabetes Commission; NAMS 2017

(MedPage Today) -- News and commentary from the endocrinology world

Sustained Response with HCV Combo Drug in CKD

(MedPage Today) -- Patients with both diseases had virologic response and no failure

Patient Care vs Primary Care: Is There a Problem Here?

(MedPage Today) -- Milton Packer asks: What about the patient?

iMedicalApps: This Week's Top Apps

(MedPage Today) -- Pediatric resuscitation, diabetes, and radiology apps make the cut

Urine test for diabetes: What you need to know

Urine tests for diabetes check for protein, ketones, and glucose. They are frequently used for diagnosing and monitoring diabetes. Learn more.

What is diabetic nephropathy?

Diabetic nephropathy is kidney disease that occurs in people with diabetes. It can cause serious complications, including kidney failure. Learn more.

Everything you need to know about prostate nodules

A prostate nodule is a firm, knuckle-like area on the prostate. There are several causes of prostate nodules, including prostatitis and prostate cancer.

Despite concerns, vasectomy and prostate cancer not linked

A debate that has raged for more than 30 years may finally be over: prostate cancer risk does not seem to be increased following a vasectomy.

Eleven ways to help prevent kidney stones

Kidney stones are crystalized minerals that form in the kidneys. They can cause a lot of pain and discomfort. We look at 11 ways to prevent kidney stones.

Suprapubic catheters: Uses, care, and what to expect

Suprapubic catheters are a type of catheter that empties urine from the bladder via an incision in the belly. Learn how to use and care for one.

Papillary urothelial carcinoma: Treatment and outlook

What is papillary urothelial carcinoma? What are the signs of papillary urothelial carcinoma, what are the causes, and what are the risk factors?

Nephroptosis: Causes, diagnosis, and treatment

A floating or mobile kidney is medically known as nephroptosis. In this article, we learn about causes, risk factors, and complications for this condition.

Why beetroot turns poop and pee red

Beetroot is widely hailed for its healthful properties. But some people find their next restroom visit a colorful experience: red poop and pee await them.

Thirteen natural home remedies for kidney stones

We look at 13 popular home remedies for treating kidney stones, how they work, the potential risks of home remedies, and when to see a doctor.

HYPERTENSION NEWS

Women's dementia risk increased by midlife hypertension

Women who develop high blood pressure in their 40s may be at greater risk of dementia, a new study finds, but this association may not ring true for men.

Regular sauna use could slash men's hypertension risk

The risk of high blood pressure may be up to 46 percent lower for men who use a sauna at least twice weekly, a Finnish study suggests.

Nephroptosis: Causes, diagnosis, and treatment

A floating or mobile kidney is medically known as nephroptosis. In this article, we learn about causes, risk factors, and complications for this condition.

Maintaining healthy weight helps keep blood pressure low through life

New research shows maintaining a healthy weight throughout life - more so than four other health behaviors studied - is important to help keep blood pressure in check, according to research presented...

PATHWAY-2 uncovers main cause of drug-resistant hypertension, finds old drugs work best

Salt retention is the main culprit behind drug-resistant hypertension (RHTN), with older diuretic medications being the most effective treatment, according to new results from the PATHWAY-2 study.

Marijuana 'may be worse than cigarettes for cardiovascular health'

Researchers suggest that the harmful effects of marijuana use on the cardiovascular system may be greater than the effects caused by cigarette smoking.

Fluctuations in home-monitored blood pressure may raise dementia risk

Whether or not you have high blood pressure, your risk of dementia may be higher if your pressure varies a lot from day to day, according to new research in the American Heart Association's journal...

Side effect to blood pressure drugs is genetically determined for some patients, study finds

Some patients may have a genetic risk of developing a serious side effect to a type of medication commonly used to treat high blood pressure, research by clinicians and scientists at the University...

Five vascular diseases linked to one common genetic variant

Genome-wide association studies have implicated a common genetic variant in chromosome 6p24 in coronary artery disease, as well as four other vascular diseases: migraine headache, cervical artery...

Weight gain in early adulthood linked to health risks later in life

Gaining a moderate amount of weight from early to middle adulthood may be associated with an increased risk of chronic disease and premature death.

GENERAL MEDICAL NEWS

Hypervirulent, carbipenem-resistant Klebsiella pneumonia outbreak in China.

Ibankcoin: Scientists in Hangzhou, China have discovered a new strain of antibiotic-resistant pneumonia which spreads incredibly fast, after a 2016 outbreak in a hospital ICU led to the deaths of five patients ranging in age from 53 to 73. In findings published in The Lancet, researchers conclude that the new superbug poses a “substantial threat to human health” due to the fact that it is “simultaneously hypervirulent, multidrug resistant, and highly transmissible.”

ISHD Hemodialysis University, Chicago, IL Sept. 7-9, 2017; with CVC insertion precourse

ISHD: Come to the ISHD 2-day Hemodialysis University, to be held in Chicago at the Oak Lawn Hilton (4 miles south of Midway Airport), Sept. 7-9th. On Thursday, September 7th, registration permitting, we will hold a precourse focusing on CVC catheter insertion. For program and registration form click on the hyperlink, or go to http://www.ishd.org.

NEJM: Idarucizumab effective for reversal of dabigatran effects.

NEJM: Conclusions. In emergency situations, idarucizumab rapidly, durably, and safely reversed the anticoagulant effect of dabigatran.

Immunotherapy may arrest damage of beta cells in type 1 diabetes.

LA Times: After a quarter-century of failed efforts to treat diabetes with an immune therapy, the experimental treatment appeared to quell the immune system’s assaults on the body’s insulin-production machinery. The authors of the new study call their experimental treatment “an appealing strategy for prevention,” both in the earliest stages of Type-1 diabetes and in children who are at high genetic risk of developing the disease.

Fresenius inks deal to acquire NxStage.

Medical Device Online: Fresenius Medical Care intends to acquire all outstanding shares of NxStage through a merger for USD 30.00 per common share, thus the transaction would be valued at approximately USD 2.0 billion. The merger, which has been approved by NxStage’s board, is subject to approval of NxStage stockholders, receipt of regulatory approvals and other customary closing conditions. Fresenius Medical Care currently expects the closing to occur in 2018.

Gene-editing of pigs increases suitability of their organs for transplant into humans.

Telegraph (Sarah Knapton): Pig organs could soon be transplanted into patients after Harvard University genetically removed a virus inherent in the animal’s DNA which makes it incompatible with humans.

Can LIF be used to cure autoimmune diseases such as multiple sclerosis? and more?

Cambridge News: Dr. Su Metcalfe of LIFNano: "We’re not using any drugs, we’re simply switching on the body’s own systems of self-tolerance and repair. There aren’t any side effects because all we’re doing is tipping the balance. Auto-immunity happens when that balance has gone awry slightly, and we simply reset that. Once you’ve done that, it becomes self-sustaining and you don’t have to keep giving therapy, because the body has its balance back."

Dr. Fred Coe's Kidney Stone Guide Book - a work in progress.

Dr. Coe: "As a way to fulfil that idea I have made and remade this book through many forms by now. Some of you have, perhaps, encountered earlier versions appearing and disappearing like ghosts. Gradually, I settled on the idea of a guide book. Here and there, in the past, I have written like a guide. My walking tours of supersaturation, for example. But this is more ambitious. I am after synthesis and cohesion because I believe they will make it easier for patients to follow the story and achieve stone prevention"

Late-breaking clinical trials at the ERA-EDTA

ERA-EDTA: NEFIGAN Trial... Novel targeted-release formulation of budesonide reduced proteinuria in IGAN patients ........................................... New insights from the COSMOS study... 12% mortality reduction, if serum phosphate levels are brought into the target range of 3.6 to 5.2 mg/dL. .................................................. Whom to treat – and not to treat – with immunosuppressive drugs?... High serum levels of Gd-IgA1 predict poor renal outcomes in IgAN ................................... Results of the EXCITE trial... A home-based exercise program significantly improves physical performance in dialysis patients ..................................... Active Vitamin D does not prevent cardiovascular disease J-DAVID Trial shows no benefit ................................ AURA-LV trial shows promising results!... Complete remission of lupus nephritis is three times more likely with voclosporin

Novel wireless device accurately measures walking speed.

Yahoo News: New York, May 2 (IANS) Researchers at Massachusetts Institute of Technology (MIT) have developed a device that can measure the walking speed of people with 95 to 99 per cent accuracy using wireless signals, without requiring that the person wear or carry a sensor. A growing body of research suggests that how fast one walks could tell a lot about health issues like cognitive decline, falls, and even certain cardiac or pulmonary diseases.

New clues to treat Alagille Syndrome from zebrafish

(Sanford-Burnham Prebys Medical Discovery Institute) A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies potential new therapeutic avenues for patients with Alagille syndrome, a rare genetic disorder caused by mutations primarily in the JAGGED1 gene.

One step closer toward a treatment for Alzheimer's disease?

(Massachusetts General Hospital) Scientists at the Massachusetts General Hospital, in collaboration with colleagues at the University California, San Diego, have characterized a new class of drugs as potential therapeutics for Alzheimer's disease and discovered a piece in the puzzle of how they would work.

Multiple Sclerosis: Oligodendrocytes from stemmcells

(Heinrich-Heine University Duesseldorf) A scientific collaboration between stem cell researchers of the Heinrich-Heine-University Duesseldorf, Germany, led by Prof. Patrick Küry (Neurology) and by Prof. James Adjaye (Stem Cell Research and Regenerative Medicine) with support from British and Chilean colleagues resulted in a publication on the prospective use of stem cells to generate cell replacement in diseases such as Multiple sclerosis (MS).

Drug yields high response rates for lung cancer patients with harsh mutation

(University of Texas M. D. Anderson Cancer Center) A targeted therapy resurrected by the Moon Shots Program™ at The University of Texas MD Anderson Cancer Center has produced unprecedented response rates among patients with metastatic non-small cell lung cancer that carries a highly treatment-resistant mutation.

Terry Fox research team's model for detecting lung cancer saves lives, is a world leader

(Terry Fox Research Institute) A pan-Canadian team of cancer researchers has developed a predictive model for detecting early-stage lung cancer in high-risk individuals with significantly greater accuracy than other leading models. This Terry Fox Research Institute study suggests the team's innovative approach could be considered for use in lung cancer screening programs both in Canada and around the world.

Superior vena cava(SVC)-derived atrial fibrillation attributes clinical and genetic factor

(Tokyo Medical and Dental University) The genetic factors associated with atrial fibrillation (AF), a condition characterized by irregular heartbeat that can lead to heart failure, have never been identified -- until now. Tokyo Medical and Dental University(TMDU) researchers conducted a study on 2,170 AF patients and discovered two genetic variants that were associated with irregular rhythmic beating in the superior vena cava. This study has successfully demonstrated that AF is associated with both clinical and genetic factors.

Diabetes foot care services may help avoid lower limb amputations

(Wiley) In a Diabetic Medicine study that compared different regions in England, areas that provided 10 key services for diabetes foot care had lower rates of major diabetes-related lower limb amputations.

From Dr. Jekyll to Mr. Hyde of cancer immunotherapy

(University of Bonn) Novel immunotherapies can strengthen the body's own defenses against cancer cells. Treatment of patients with advanced disease can promote partial and complete tumor regressions. However, such strategies also frequently fail. The underlying mechanisms are incompletely understood. An international research team led by the University Hospitals of Magdeburg and Bonn has now discovered a previously unrecognized braking mechanism that limits the efficacy of cancer immunotherapies. The results provide a scientific basis to further develop cancer immunotherapy.

Gene therapy can cure lameness in horses, research finds

(University of Nottingham) Injecting DNA into injured horse tendons and ligaments can cure lameness, new research involving scientists at Kazan Federal University, Moscow State Academy and The University of Nottingham has found.

NTU and Saab partnership to develop innovative high-end digital technology

(Nanyang Technological University) Nanyang Technological University (NTU Singapore) and Swedish defence and security technology leader Saab will set up a joint research centre as part of a collaboration to develop research projects and programmes in high-end digital technology. The collaboration with NTU is the first of its kind in Asia for Saab.