KIDNEY / NEPHROLOGY NEWS

Partial Nephrectomy for Small Renal Tumors Offers Survival Edge

Partial vs radical nephrectomy is associated with an overall survival advantage among patients with RCC tumors 4 cm or smaller and many patients with larger tumors.

Kidney Transplant Outcomes Unaffected by Dialysis Modality

Patient and graft survival are similar for patients who were on hemodialysis and peritoneal dialysis prior to transplantation.

Statin Use in Advanced CKD Lowers Death Risk

Researchers report a significant 41% decreased mortality risk among patients with advanced CKD who used statins compared with those who did not.

Trilobites: Kidney Stones Are More Beautiful Than You Might Think

New research found that the painful deposits are surprisingly dynamic, forming much like microscopic coral reefs, and could help with treating them.

CERTAIN ENVIRONMENTAL POLLUTANTS MAY CONTRIBUTE TO POOR KIDNEY HEALTH

In an analysis of all relevant studies, exposure to environmental toxins called per- and polyfluoroalkyl substances was linked to worse kidney function and other signs of kidney damage.

AMERICAN SOCIETY OF NEPHROLOGY PARTNERS WITH RENAL FELLOW NETWORK BLOG

On the 10th anniversary of the Renal Fellow Network (RFN), one of the first nephrology blogs, the American Society of Nephrology has created a partnership with RFN to continue its legacy and forge new opportunities.

Gout Attack Risk Lowered With Interleukin-1ß Blockade

Inhibition of IL-1ß with canakinumab significantly decreased gout attack risk at all baseline serum uric acid (SUA) levels and without changing SUA levels.

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

Over a 5-year period, the drug was well tolerated and associated with significant declines in urinary protein-creatinine ratio and mean prednisolone dose.

Study overturns what we know about kidney stones

New research uses cutting-edge technology to study kidney stones. The findings change what we know about their nature, composition, and behavior.

Higher Caffeine Intake May Decrease Death Risk in CKD

Among individuals with chronic kidney disease, those in the top quartile of daily caffeine consumption had a 25% lower risk of death vs those in the bottom quartile.

TMVR Benefits Hold Firm in Post-Market Registry (CME/CE)

(MedPage Today) -- Do data point to a future 'transcatheter toolbox' for mitral disease?

Multivessel PCI Not Best in Cardiogenic Shock

(MedPage Today) -- Trial data show mortality disadvantage versus treating culprit lesions only

ASN 2017: The Future of Personalized Nephrology

(MedPage Today) -- Tissue engineering, drug discovery challenges among highlight topics

10 Questions to Challenge Your Medical News Savvy

(MedPage Today) -- Weekly News Quiz: October 20-26

Surgical Weight Loss; Low hs-cTNT Still Risky; VAD Before Pediatric Transplant

(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week

EndoBreak: T1D and Vitamin D; VA's T2D Guideline; Oral Acromegaly Drug

(MedPage Today) -- News and commentary from the endocrinology world

For SAVR, Afternoon Tops Morning for Surgical Safety (CME/CE)

(MedPage Today) -- Circadian genes appear to interact with ischemia-reperfusion injury effects

Robotic-Assisted Surgery Adds Time, Costs Without Affecting Outcomes (CME/CE)

(MedPage Today) -- No improvements compared with laparoscopic procedures in kidney removal and rectal cancer

RAS Blockade After TAVI Tied to Better Outcomes (CME/CE)

(MedPage Today) -- Patients with severe aortic stenosis see reduced all-cause mortality

Borderline Pulmonary Hypertension Tied to Mortality Risk

(MedPage Today) -- Small increases in pressure might signal left heart failure, not early PAH

What can make urination painful?

There are many possible causes of painful urination, or dysuria, including bacterial infections and health conditions that place extra pressure on the bladder. Fortunately, most of these potential causes are highly treatable. Learn more about 10 causes of dysuria here, as well as when to see a doctor.

Study overturns what we know about kidney stones

New research uses cutting-edge technology to study kidney stones. The findings change what we know about their nature, composition, and behavior.

Treating urinary tract infections with Cipro

Cipro is an antibiotic that doctors use to treat urinary tract infections (UTIs). For Cipro to work, people must take the full course of the drug and follow their doctor's instructions. But some people may be at risk of severe side effects if they take Cipro, and they may need to consider alternatives. Learn more here.

Urologic conditions lead to depression, sleep issues in men

Physicians need to be aware that men with urologic conditions often have depression and sleep problems and should refer them appropriately, says a study.

Vitamin B-3 may treat and prevent acute kidney injury

New research shows that raising vitamin B-3 levels may benefit patients who have undergone major surgery and are at risk of developing acute kidney injury.

What are the symptoms of a UTI in older adults?

Urinary tract infections (UTIs) can affect people at any age. However, UTIs are one of the most common causes of infection in older adults. Symptoms of a UTI in older adults may include restlessness, agitation, and confusion. UTIs are treatable with medication. Learn more about UTIs in seniors here.

How to do pelvic floor exercises

The pelvic floor is a set of muscles that supports pelvic organs, including the bladder and bowel. These muscles aid urinary control, continence, and orgasm. In this article, learn how to do four exercises that can help strengthen the pelvic floor, including bridge and squats. We also cover which exercises to avoid.

What to do about an evaporation line on a pregnancy test

An evaporation line on a pregnancy test is a faint, non-colored line that may appear if a person uses the test incorrectly. In this article, learn to tell the difference between an evaporation line and a positive test result. We also describe how pregnancy tests work and how to prevent evaporation lines from appearing.

What are the symptoms of late stage bladder cancer?

The symptoms of stage 4 bladder cancer include tiredness, weakness, and pain. Stage 4 is the most advanced stage of cancer. The standard treatment for late-stage cancer is chemotherapy, but treatment will often focus on palliative care. Learn more about the symptoms of stage 4 bladder cancer and the survival rate here.

Why is my kid's poop green?

Green poop in kids is usually due to something that they ate, such as leafy greens or food coloring. Diarrhea can also cause green poop. Green poop is rarely a need for worry, and in infants, it is a sign that everything is normal. Learn about the reasons for green poop in babies, toddlers, and children here.

HYPERTENSION NEWS

High blood pressure breakthrough: Over 500 genes uncovered

The world's largest genetic study of hypertension finds that the number of genetic loci involved is three times larger than previously thought.

Inhaled blood pressure drug could prevent panic attacks

New research suggests that a drug commonly used for hypertension could be used as a quick-acting nasal spray to prevent anxiety attacks.

Can a 16-week lifestyle intervention impact blood pressure?

A recent study demonstrates that simply changing diet and increasing exercise can significantly reduce blood pressure in just 16 weeks.

Cardiovascular disease: Study finds best drugs for prevention

A large cohort study finds out which treatments work best to prevent cardiovascular events in individuals with hypertension and other risk factors.

High blood pressure? Turn up your thermostat

The temperature of your house might influence your blood pressure. A new report suggests that cooler houses may worsen hypertension.

New 'triple pill' could eliminate high blood pressure

Hypertension is very common, and it's a major cardiovascular risk factor. An innovative 'three in one' pill may help treat it more easily and effectively.

E-counseling can lower blood pressure, heart disease risk

New research shows that virtual counseling, when added to medical therapy, lowers high blood pressure and heart disease risk in people with hypertension.

Is it true that 'healthy obesity' boosts death risk?

New research questions whether metabolically healthy obesity — obesity without diabetes, hypertension, or high cholesterol — actually increases mortality.

Can high blood pressure lead to headaches?

High blood pressure, also called hypertension, has many potential symptoms. These may include back pain, difficulty sleeping, and shortness of breath. Some research also suggests that very high blood pressure can cause headaches. Treatment depends on the causes. Learn more about high blood pressure and headaches here.

High blood pressure may increase dementia risk

A new study looking at links between hypertension in later life and brain health finds an increased risk of Alzheimer's hallmarks and brain lesions.

GENERAL MEDICAL NEWS

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Clinical trial investigators violate EU regulations: Entries in EU Register are incomplete

(Institute for Quality and Efficiency in Health Care) Compliance of pharma companies is relatively good, but very poor for university research groups. Research funders should make allocation of further funding dependent on data transparency.

Promising phase 1/2 results for entrectinib against ROS1+ non-small cell lung cancer

(University of Colorado Anschutz Medical Campus) Results of phase 1 and phase 2 clinical trials of the drug entrectinib in ROS1-positive non-small cell lung cancer (NSCLC) presented on the press program of the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer show a response rate of 77.4 percent for 53 patients evaluable for response, with median duration of response of 24.6 months.

Lawnmower injuries a persistent source of serious injury and high costs, new study affirms

(Johns Hopkins Medicine) In what Johns Hopkins Medicine researchers call an unusually comprehensive analysis of nationwide data, they conclude that the rate of lawnmower injuries persists at close to 6,400 a year, most of them requiring surgery and hospitalization, and costing an average of $37,000 per patient.

Lancaster professor to research how genes affect quitting smoking

(Lancaster University) The Canadian Institute of Health Research has awarded $929,475 to Professor Jo Knight of Lancaster University and the University of Toronto with collaborators from across the United States. Their aim is to understand how genetic variation can be used to optimize smoking cessation treatment choice using data from nine existing clinical trials with more than 5,000 smokers.

Dosimetry and toxicity studies of a sulfonamide derivative of Sulforhodamine 101

(Bentham Science Publishers) The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye SR101 has been reported as a marker of astroglia in the neocortex of rodents in vivo. The aim of this study was to perform a toxicological evaluation of [18F]SRF101 and to estimate human radiation dosimetry based on preclinical studies.

The theranostic complex with two toxic modules shows great toxicity for tumour cells

(Lobachevsky University) Emerging cancer nanotechnology enables target-delivery of substantial payloads of drugs to cancer sites with concomitant reduction of side-effects due to the lesser accumulation in the critical organs. This prompts loading of nanocarriers with therapeutic cargo and contrast agents, allowing combined cancer therapy and tumour visualization, respectively. Researchers from Lobachevsky University of Nizhny Novgorod, Russia, have implemented such combined therapy using conjugates of radionuclide yttrium-90-doped upconversion nanoparticles (UCNP) and targeted toxin.

Call for new approaches to fill significant gaps in understanding Parkinson's disease

(Humane Society International) New paper calls for the use of advances human-relevant methods to enable understanding of the initiation and progression of Parkinson's disease.

A new remedy for celiac disease

(Vienna University of Technology) In an industrial collaboration project, TU Wien has developed a medication that can alleviate or even completely eliminate the symptoms of celiac disease. It should be available as early as 2021.

Does our environment affect the genes in our brains?

(Charité - Universitätsmedizin Berlin) Is there a link between differences in IQ test performance and the activity of certain genes? Researchers from Charité -- Universitätsmedizin Berlin have shown that modifications in the structure of a specific gene have a negative impact on individual test performance. This suggests that environmentally-induced epigenetic changes to our genetic material have a greater impact on intelligence than previously thought. Results from this study have been published in Translational Psychiatry.

Results from the ReCre8 trial reported at TCT 2018

(Cardiovascular Research Foundation) The first large, randomized trial comparing a novel polymer-free amphilimus-eluting stent to the latest-generation permanent polymer drug-eluting stent found that the polymer-free stent was clinically safe and effective.